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  MALVERN

Differential Scanning Calorimetry

Confident characterization of protein stability

Differential Scanning Calorimetry (DSC) is a technique used to characterize the stability of a protein or other biomolecule directly in its native form. It does this by measuring the heat change associated with the molecule’s thermal denaturation when heated at a constant rate.

Dynamic Light Scattering (DLS)

Dynamic Light Scattering DLS for particle size characterization of proteins, polymers and colloidal dispersions

Dynamic light scattering (DLS), sometimes referred to as Quasi-Elastic Light Scattering (QELS), is a non-invasive, well-established technique for measuring the size and size distribution of molecules and particles typically in the submicron region, and with the latest technology lower than 1nm.

 

Electrophoretic Light Scattering (ELS)

Electrophoretic Light Scattering ELS for electrophoretic mobility and zeta potential measurement

Electrophoretic Light Scattering (ELS) is a technique used to measure the electrophoretic mobility of particles in dispersion, or molecules in solution. This mobility is often converted to Zeta potential to enable comparison of materials under different experimental conditions.

 

Gel Permeation Chromatography (GPC)

Gel Permeation Chromatography (GPC) for measurement of polymer molecular weight, size and structure.

Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.

 

Image Analysis

Direct measurement of particle size and particle shape.

Automated imaging is a high resolution direct technique for characterizing particles. Individual particle images are captured from dispersed samples and analyzed to determine their particle size, particle shape and other physical properties. Statistically representative distributions can be constructed by measuring 10’s to 100’s of thousands of particles per measurement.

 

Isothermal Titration Calorimetry

Label-free measurement of the binding affinity and thermodynamics of biomolecular interactions to understand function and mechanisms at a molecular level

Isothermal Titration Calorimetry (ITC) is a technique used in quantitative studies of a wide variety of biomolecular interactions. It works by directly measuring the heat that is either released or absorbed during a biomolecular binding event.

 

Laser Diffraction

Particle size distributions from nanometers to millimeters.

Laser diffraction is a widely used particle sizing technique for materials ranging from hundreds of nanometers up to several millimeters in size. 

 

Nanoparticle Tracking Analysis

Visualize and measure particle size and concentration

Nanoparticle Tracking Analysis (NTA) utilizes the properties of both light scattering and Brownian motion in order to obtain the particle size distribution of samples in liquid suspension.

 

Raman spectroscopy

Chemical identification of particulates

Raman spectroscopy is an established spectroscopic technique for measuring the chemical identity and structure of materials across many industries, including pharmaceuticals, fine chemicals, minerals and foods.

 

Resonant mass measurement

Detection and quantification of protein aggregates and other particles in formulation

Resonant mass measurement is a technique used in an innovative way by Archimedes to detect and count sub visible and submicron particles in a sample, and to measure their size and mass and distributions of size and mass. At the heart of Archimedes is a MEMS (micro Electro-Mechanical Systems) sensor, containing a resonating cantilever with a microfluidic channel embedded in its surface. When a particle of between 50nm - 5µm flows through the fluidic channel, it alters the resonating frequency of the cantilever which indicates the buoyant mass, and also the dry mass and size of the particle.

 

Rheometry - capillary

Rheometers for characterizing material rheology for high force and high shear rate extrusion.

Capillary rheometry has its origins in polymer melt processing, but is also directly relevant to many other material processes such as high speed coating and printing applications. Based on controlled extrusion of a test material, capillary rheometry enables material flow and deformation properties to be characterized under conditions of high force (or pressure), high shear rate and at elevated temperature.

 

Rheometry - rotational

Rotational rheometers for measuring viscosity and viscoelasticity.

Rotational rheometry is a powerful technique for the measurement of complex shear rheology across all material types – sensitive enough to measure the viscosity of dilute polymer solutions, and yet robust enough to measure the viscoelasticity of high modulus polymers or composites. Rotational rheometry is ideal for discerning structural and compositional changes of materials, which can be critical controlling factors in flow and deformation properties, and ultimately product stability and performance.

 

Size Exclusion Chromatography (SEC)

Size exclusion chromatography (SEC or SEC-HPLC) for measurement of protein absolute molecular weight, structure, size and conformation

Size Exclusion Chromatography (SEC or SEC-HPLC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.