Bridging the gap between in vitro experiments and in vivo outcomes
Get better in vitro/in vivo correlation (IVIVC) and PhysioChemical Indicators for solubility, absorption, and permeability. Accelerate your pharmaceutical formulation development with next-generation technology. As a leading analytical instrument company, Pion supports your research with in vitro scientific instruments, analytical services, and equipment to deliver the accuracy of results required for more predictive decision-making in the drug development process.
FEATURED SOLUTIONS
Dissolution Testing / Pharmaceutical Applications
Dissolution analysis, including USP dissolution, is crucial to effective drug development. Yet, traditional dissolution approaches can be inefficient and time-consuming, delaying progress and consuming resources. Pion dissolution testing equipment is engineered to support every step of the drug development process.
MicroDISS Profiler™
The MicroDISS Profiler™ is an innovative insitu fiber optic UV monitoring system, specifically designed to monitor concentration in real-time from small volume dissolution assays. It is powered by AuPRO™; the most comprehensive dissolution data analysis software in the industry.
miniDISS Profiler™ for Biorelevant Dissolution
The miniDISS Profiler™ is a Rainbow in situ Fiber Optic UV monitoring system with the miniDT dissolution tester and is designed for biorelevant media volumes. It is ideal for measuring high-potency API or when low concentrations are expected, typical of Pre-Formulation and Formulation activities. Designed to work with the Pion Rainbow Dynamic Dissolution Monitor, the miniDT Dissolution Tester may be used independently.
Rainbow® Dynamic Dissolution Monitor
The UV fiber optic-based Rainbow® Dynamic Dissolution Monitor is a powerful tool, designed to deliver the fastest path to accurate dissolution analysis. Built with a world-class optical bench, it allows for simultaneous real-time data collection and analysis of up to 8 vessels through a user-friendly software interface. It's the detection core of the MicroDISS Profiler.
SDi2
Surface imaging is an increasingly important tool in effective drug development, and the SDI2 puts scientists right there at the interface, enabling you to monitor the dissolution of APIs in real time – and also to record the process for subsequent analysis. The SDI2 captures the action in both the visible light and the UV spectrum.
inForm
Biphasic Dissolution techniques can establish more accurate correlations between in-vitro and in-vivo outcomes than conventional dissolution methods alone. Inform’s fibre-optic technology can be highly effective in supporting biphasic dissolution studies. Ten of the world’s top ten pharmaceutical companies use Pion’s fibre-optic technology to support biphasic dissolution measurement.
In vitro Imaging & Testing
The role of biopharmaceutical analysis has grown rapidly in the past 30 years, driven by the discovery of new molecules and innovative therapies. However, drug form and formulation can both impact release and absorption, and scientists need new ways to understand and predict these effects. Pion is a true pioneer in in vitro drug testing, with an innovative and ever-growing range of specialist instruments.
MacroFLUX™
With Pion’s MacroFLUX device, you can reliably test and rank the absorption potential of formulations and finished drug products in vitro. This is accomplished using a standard USP dissolution set-up coupled with an absorption chamber along with fiber optic UV detection and can greatly enhance in vivo prediction.
MicroFLUX™
Pion’s MicroFLUX allows you to combine data from a dissolution experiment with transmembrane permeation. It is the perfect in vitro tool to support pharmacokinetic (PK) prediction and decision-making.
inForm
inForm is a powerful tool that bridges the gap between research-based micro-scale dissolution and the compendial world. It allows for precise pH control and monitoring, enabling you to study dissolution under conditions that mimic in vivo conditions more closely that other systems. inForm can be used to provide biorelevant dissolution and solubility data to help you make formulation decisions more effectively.
BioFLUX™
Pion's BioFLUX device is an extension to Pion’s flux device family. It’s designed to improve the utility of in-site concentration monitoring with 200-250 mL dissolution volumes. BioFLUX employs in-site fibre-optic UV detection in both its donor and receiver chambers to generate the required data density for close assessment of transmembrane flux. Research scientists are now able to accurately test finished dosage forms under biorelevant conditions.
PAMPA
Pion’s PAMPA technology uses a range of membranes to mimic gastrointestinal conditions or the blood-brain barrier or human skin. It allows you to evaluate the passive permeability of API's as well as the absorption potential of simple or complex formulations very precisely using robust models and protocols.
Gut-Box™
Gut-Box is Pion’s mechanical stirring apparatus, specially designed for use with PAMPA. It supports the 96 well-plate set-up. When used in conjunction with PAMPA, Gut-Box provides stirring that mimics that found in the gastro-intestinal tract (GIT).
TempPlate
TempPlate is Pion’s temperature control unit, specially designed for use with PAMPA and other 96-well plate format assays. TempPlate allows you to set and maintain precise temperatures for all your key experiments.
MicroDISS Profiler™
The MicroDISS Profiler is an innovative in-situ fiber optic UV monitoring system, specifically designed to monitor small volume concentrations. It is powered by AuPRO™; the most comprehensive data analysis software in the industry.
SiriusT3
The SiriusT3 is an automated instrument for compound screening and PhysChem profiling, featuring Pion's CheqSol method to determine solubilities of ionizable compounds. It provides detailed information on supersaturation, pH-solubility profile, and takes less than 2 hours. ‘SiriusT3 is the Gold Standard.’
SCISSOR N3
The first instrument designed specifically to assess the risk and performance of subcutaneously administered drugs including biologics, peptides and small molecules. Scissor provides the ability to rank order release curves in a human bio-relevant setting for effective formulation screening and candidate selection during development.
SDi2
The SDi2 is a unique UV and visible light imaging tool which allows scientists to observe precisely what is happening at the solid-liquid interface during the dissolution process, gaining a greater understanding of how their products behave during dissolution. It enables the accurate measurement of intrinsic dissolution and release rates alongside monitoring the swelling, erosion and disintegration processes for a wide range of whole dosage forms.
Physicochemical Analysis Tools
The results of PhysChem analysis form the foundations on which much of the process of drug development is based. Expertise in PhysChem analysis is also one of the principles on which Pion was founded and where we’ve continued to build our reputation. Pion's key strengths in PhysChem Analysis include ionization, pKa, LogP, Solubility, Dissolution and Permeability.
SiriusT3
Pion’s SiriusT3 is a fully automated instrument designed for compound screening and preparing detailed PhysChem profiles. It gives you accurate data using only small sample quantities and can manage up to 8 solubility assays per day.
MicroDISS Profiler™
The MicroDISS Profiler is an innovative in-situ fiber optic UV monitoring system, specifically designed to monitor small volume concentrations. It is powered by AuPRO™; the most comprehensive data analysis software in the industry.
inForm
inForm is a powerful tool that allows you to study solubility under conditions that mimic those found in the body and environment, while providing detailed bio-relevant dissolution and solubility data to help you make formulation decisions more efficiently.
Sample Preparation
Solutions for extraction and mixing, sample preparation, content uniformity, impurity, and assay development. Quickly becoming a standard with pharmaceutical and companies of all sizes. Pharmaceutical, biopharmaceutical and cannabis industry customers benefit from richer, more relevant insights about product behavior and ideal formulation conditions.
PrepEngine
PrepEngine is a flexible life science processing platform that can extract materials into solution, mix, centrifuge, lyse and more. PrepEngine is modular and is ready to add automation and control to your process. With modules for extraction, mixing, centrifugation, lysing, and more, you’ll be able to overcome your toughest challenges.
Laboratories can be harsh environments. Designed to fit your lab, our cameras are specifically designed to be right at home in difficult surroundings. All recordings are further protected, traceable, and secure, within a command center. A built-in scheduler makes recording and organizing your visual data easy. Within minutes, Pion's cameras can be placed in your lab and and will start gathering valuable data.
LabEye
The LabEye system is a scalable multi-camera system that uses high-resolution cameras to record video for remote monitoring applications.
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