Aging

Aging is a fundamental biological process with an enormous impact on global healthcare. Understanding how the proteome changes with biological and chronological age is accelerating progress in this rapidly developing field.

Cardiovascular diseases

Proteomics provides important insights into major health issues like coronary artery disease, atrial fibrillation, and heart failure. These studies advance understanding of the underlying pathways and risk factors and how they link to associated comorbidities.

Immunological and inflammatory diseases

Sensitive, accurate measurement of the plethora of immune response proteins that interact with each other, and multiple cell types is essential to better understand the complexity of immune system responses and the changes underlying autoimmune and inflammatory diseases.

Neurological diseases

Blood and cerebrospinal fluid (CSF) proteomics enable a deeper understanding of disease biology, assessment of risk, diagnosis, and monitoring of key neurological conditions such as Alzheimer’s disease, traumatic brain injury, multiple sclerosis, and chronic pain.

Oncology and immuno-oncology

Adding a much-needed layer of resolution to genomic data, proteomic studies are identifying new diagnostic, prognostic, and long-range risk biomarkers for multiple cancers and providing invaluable insights into the complexities of immuno-oncology.